Study on the pathogenicity, immunogenicity, endogenous development and drug sensitivity of Eimeria kongi

Frontiers in Veterinary Science

Veterinary Science

Peng Wang¹  Lihui Guan¹  Sufang Fang¹  Ping Cui¹  Yubo Shi¹  Xiaolong Gu¹  Xun Suo²  Chen Guan³ 

[1] College of Animal Science and Technology, Hebei North University, Zhangjiakou, Hebei, China;National Key Laboratory of Veterinary Public Health Security, Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, Beijing, China;National Animal Protozoa Laboratory and College of Veterinary Medicine, China Agricultural University, Beijing, China;Zhangjiakou Animal Husbandry Technology Promotion Station, Zhangjiakou, Hebei, China;

关键词: Eimeria kongi;    pathogenicity;    immunogenicity;    endogenous development;    drug sensitivity;   

DOI  :  10.3389/fvets.2023.1134193

 received in 2022-12-30, accepted in 2023-02-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Following the discovery of Eimeria kongi, we investigated the pathogenicity, immunogenicity, endogenous development and drug sensitivity of this coccidian. Coccidia-free rabbits were inoculated with 1 × 102 to 5 × 104 sporulated oocysts of E. kongi before challenge 14 days post inoculation. E. kongi was moderately pathogenic and induced good immunity against re-infection. All inoculated doses results in reduced food intake and body weight gain, and an inoculation oocyst dose of 1 × 103 or higher caused various degrees of diarrhea. Except for one death of the highest dose group, all rabbits recovered 12 days post inoculation. An inoculation dose of 1 × 103 or 1 × 104 oocysts conferred the most effective protection from re-infection, which reduced oocyst output by approximately 99% and maintained body weight gain. Four generations of schizogony were observed, and the endogenous development mainly occurred in the jejunum and ileum of rabbits. E. kongi was most sensitive to sulfachloropyrazine sodium, followed by decoquinate; it is resistant to diclazuril. Both decoquinate and sulfachloropyrazine sodium may be effective in the control of E. kongi infection.

【 授权许可】

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Copyright © 2023 Fang, Shi, Wang, Guan, Gu, Guan, Cui and Suo.