Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial

Frontiers in Nutrition

Nutrition

Dan Li¹  Ju Yang¹  Jiai Yan¹  Jing Sun¹  Yingyu Wang¹  Yanping Xia¹  Hong Cao¹  Baixi Zhang²  Yiwei Yang³  Feng Zhang⁴ 

[1] Department of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, China;Clinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, China;Yixing Institute of Food and Biotechnology Co., Ltd., Yixing, China;School of Food Science and Technology, Jiangnan University, Wuxi, China;Wuxi School of Medicine, Jiangnan University, Wuxi, China;Department of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, China;Clinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, China;Wuxi School of Medicine, Jiangnan University, Wuxi, China;Department of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, China;Clinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, China;Yixing Institute of Food and Biotechnology Co., Ltd., Yixing, China;

关键词: n-6/ n-3 polyunsaturated fatty acids ratio;    cardiometabolic health;    hyperlipidemia;    lipid metabolism;    perilla oil;   

DOI  :  10.3389/fnut.2023.1166702

 received in 2023-02-15, accepted in 2023-05-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and aimsIntake of n-3 polyunsaturated fatty acids (PUFA) is helpful for cardiometabolic health. It improves lipid metabolism, and increasing n-3 PUFA is often considered beneficial. However, the role of n-6/n-3 in the regulation of lipid metabolism has been much debated. Therefore, this study was performed on the effect of different proportions of n-6/n-3 diet on lipid metabolism, and quality of life in patients with hyperlipidemia, aiming to explore appropriate proportions of n-6/n-3 to provide the theoretical basis for the development and application of nutritional blended oil in the future.MethodsThese 75 participants were randomized and assigned into three groups, which received dietary oil with high n-6/n-3 PUFA ratios (HP group: n-6/n-3 = 7.5/1), dietary oil with middle n-6/n-3 PUFA ratios (MP group: n-6/n-3 = 2.5/1) or low n-6/n-3 PUFA ratios (LP group: n-6/n-3 = 1/2.5). All patients received dietary guidance and health education were monitored for hyperlipidemia. Anthropometric, lipid and blood glucose parameters and quality of life were assessed at baseline and 60 days after intervention.ResultAfter 60 days, high-density lipoprotein cholesterol (HDL-c) level was increased (p = 0.029) and Total cholesterol (TC) level was decreased (p = 0.003) in the MP group. In the LP group, TC level was decreased (p = 0.001), TG level was decreased (p = 0.001), but HDL-c level was not significantly increased. At the end of intervention, quality of life’ score was improved in both MP and LP groups (p = 0.037).ConclusionDecreasing the intake of edible oil n-6/n-3 ratio can improve blood lipids and quality of life. This is significant for the prevention of cardiovascular disease (CVD). It is also essential to note that an excessive reduction of the n-6/n-3 ratio does not further improve the blood lipid metabolism. In addition, the application of perilla oil in nutritional blended oil has particular significance.Clinical trial registrationhttps://www.chictr.org.cn/indexEN.html, identifier ChiCTR-2300068198.

【 授权许可】

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Copyright © 2023 Yang, Xia, Zhang, Li, Yan, Yang, Sun, Cao, Wang and Zhang.