期刊论文详细信息
Frontiers in Immunology | |
A systems serology approach to the investigation of infection-induced antibody responses and protection in trachoma | |
Immunology | |
Robin L. Bailey1  David C. W. Mabey1  Anna Harte1  Amber Barton1  Martin J. Holland1  Harry Pickering1  Anja Weinreich Olsen2  Ida Rosenkrands2  Jes Dietrich2  Frank Follmann2  Hassan Joof3  Manon Ragonnet3  Pateh Makalo3  Nkoyo Faal3  | |
[1]Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom | |
[2]Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark | |
[3]Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, Gambia | |
关键词: trachoma; Chlamydia trachomatis; antibody; systems serology; IgG; humoral immunity; | |
DOI : 10.3389/fimmu.2023.1178741 | |
received in 2023-03-03, accepted in 2023-05-02, 发布年份 2023 | |
来源: Frontiers | |
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【 摘 要 】
BackgroundOcular infections with Chlamydia trachomatis serovars A–C cause the neglected tropical disease trachoma. As infection does not confer complete immunity, repeated infections are common, leading to long-term sequelae such as scarring and blindness. Here, we apply a systems serology approach to investigate whether systemic antibody features are associated with susceptibility to infection.MethodsSera from children in five trachoma endemic villages in the Gambia were assayed for 23 antibody features: IgG responses towards two C. trachomatis antigens and three serovars [elementary bodies and major outer membrane protein (MOMP), serovars A–C], IgG responses towards five MOMP peptides (serovars A–C), neutralization, and antibody-dependent phagocytosis. Participants were considered resistant if they subsequently developed infection only when over 70% of other children in the same compound were infected.ResultsThe antibody features assayed were not associated with resistance to infection (false discovery rate < 0.05). Anti-MOMP SvA IgG and neutralization titer were higher in susceptible individuals (p < 0.05 before multiple testing adjustment). Classification using partial least squares performed only slightly better than chance in distinguishing between susceptible and resistant participants based on systemic antibody profile (specificity 71%, sensitivity 36%).ConclusionsSystemic infection-induced IgG and functional antibody responses do not appear to be protective against subsequent infection. Ocular responses, IgA, avidity, or cell-mediated responses may play a greater role in protective immunity than systemic IgG.【 授权许可】
Unknown
Copyright © 2023 Barton, Rosenkrands, Pickering, Faal, Harte, Joof, Makalo, Ragonnet, Olsen, Bailey, Mabey, Follmann, Dietrich and Holland
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