Mean platelet volume, platelet count, and neutrophil/lymphocyte ratio in drug-naïve patients with schizophrenia: a cross-sectional study

Frontiers in Psychiatry

Psychiatry

Marisol Basurto-Morales¹  Elizabeth Botello-Aceves²  Héctor Cabello-Rangel³  Osiris Pazarán-Galicia³ 

[1] Clinic Laboratory Department, Hospital Psiquiátrico Infantil “Juan N. Navarro”, Ciudad de México, Mexico;Medical Student, Universidad Quetzalcóatl, Irapuato, Guanajuato, Mexico;Research Department, Hospital Psiquiátrico “Fray Bernardino Álvarez”, Ciudad de México, Mexico;

关键词: platelets;    mean platelet volume;    schizophrenia;    neutrophil/lymphocyte ratio;    psychosis;   

DOI  :  10.3389/fpsyt.2023.1150235

 received in 2023-01-23, accepted in 2023-03-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionMean platelet volume (MPV), platelet count, and neutrophil/lymphocyte ratio (NLR) have been proposed to be biomarkers of the chronic inflammatory process in schizophrenia and indicative of increased cardiovascular risk.ObjectiveTo describe MPV, total platelet count (PLT), and NLR between healthy controls and patients with schizophrenia to determine the correlation between these parameters and the duration of untreated psychosis (DUP).MethodsIn a retrospective cross-sectional study, we included 175 patients with schizophrenia who had never received psychiatric treatment, and who had undergone blood biometry and blood chemistry within 24 h of admission. Laboratory studies were determined by the impedance method on Coulter ac-T 5 diff hematological equipment.ResultsMean platelet volume levels in patients with schizophrenia were higher than in healthy controls but not statistically significant. The receiver operating characteristic curve for this parameter shows that the optimal cutoff point of agreement was 8.95 fL, with sensitivity and specificity for schizophrenia of 52% and 67%, respectively, and the area under the curve (AUC) was 0.580 (p = 0.079). DUP had no significant correlation with the blood parameters analyzed.ConclusionThe results partially support the hypothesis that MPV, platelet count, and NLR is related to schizophrenia, and further research is needed to establish whether there is an underlying chronic inflammatory process.

【 授权许可】

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Copyright © 2023 Cabello-Rangel, Basurto-Morales, Botello-Aceves and Pazarán-Galicia.