Relationship between air pollution exposure and the progression of idiopathic pulmonary fibrosis in Madrid: Chronic respiratory failure, hospitalizations, and mortality. A retrospective study

Frontiers in Public Health

Public Health

Ester Zamarrón¹  Carlos Carpio¹  Rodolfo Álvarez-Sala¹  Concepción Prados¹  Pablo Mariscal-Aguilar¹  Luis Gómez-Carrera¹  Francisco Gayá²  Mariana Díaz-Almirón²  Isabel Esteban³  Rita Regojo³  Elena Villamañán⁴  Isabel Torres⁵  María Fernández-Velilla⁵  Gema Bonilla⁶ 

[1] Department of Respiratory Medicine, Hospital Universitario La Paz, Madrid, Spain;Research Institute of Hospital Universitario La Paz (IdiPAZ), Madrid, Spain;Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Spain;Research Institute of Hospital Universitario La Paz (IdiPAZ), Madrid, Spain;Research Institute of Hospital Universitario La Paz (IdiPAZ), Madrid, Spain;Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;Department of Pathological Anatomy, Hospital Universitario La Paz, Madrid, Spain;Research Institute of Hospital Universitario La Paz (IdiPAZ), Madrid, Spain;Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;Department of Pharmacy, Hospital Universitario La Paz, Madrid, Spain;Research Institute of Hospital Universitario La Paz (IdiPAZ), Madrid, Spain;Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;Department of Radiology, Hospital Universitario La Paz, Madrid, Spain;Research Institute of Hospital Universitario La Paz (IdiPAZ), Madrid, Spain;Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain;

关键词: air pollution;    idiopathic pulmonary fibrosis;    chronic respiratory failure;    hospital admissions;    mortality;   

DOI  :  10.3389/fpubh.2023.1135162

 received in 2022-12-31, accepted in 2023-02-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionAir pollution has a significant impact on the morbidity and mortality of various respiratory diseases. However, this has not been widely studied in diffuse interstitial lung diseases, specifically in idiopathic pulmonary fibrosis.ObjectiveIn this study we aimed to assess the relationship between four major air pollutants individually [carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), and nitrogen oxides (NOx)] and the development of chronic respiratory failure, hospitalization due to respiratory causes and mortality in patients with idiopathic pulmonary fibrosis.MethodsWe conducted an exploratory retrospective panel study from 2011 to 2020 in 69 patients with idiopathic pulmonary fibrosis from the pulmonary medicine department of a tertiary hospital. Based on their geocoded residential address, levels of each pollutant were estimated 1, 3, 6, 12, and 36 months prior to each event (chronic respiratory failure, hospital admission and mortality). Data was collected from the air quality monitoring stations of the Community of Madrid located <3.5 km (2.2 miles) from each patient's home.ResultsThe increase in average values of CO [OR 1.62 (1.11–2.36) and OR 1.84 (1.1–3.06)], NO2 [OR 1.64 (1.01–2.66)], and NOx [OR 1.11 (1–1.23) and OR 1.19 (1.03–1.38)] were significantly associated with the probability of developing chronic respiratory failure in different periods. In addition, the averages of NO2, O3, and NOx were significantly associated with the probability of hospital admissions due to respiratory causes and mortality in these patients.ConclusionAir pollution is associated with an increase in the probability of developing chronic respiratory failure, hospitalization due to respiratory causes and mortality in patients with idiopathic pulmonary fibrosis.

【 授权许可】

Unknown   
Copyright © 2023 Mariscal-Aguilar, Gómez-Carrera, Carpio, Zamarrón, Bonilla, Fernández-Velilla, Torres, Esteban, Regojo, Díaz-Almirón, Gayá, Villamañán, Prados and Álvarez-Sala.