Psychiatric traits and intracerebral hemorrhage: A Mendelian randomization study

Frontiers in Psychiatry

Psychiatry

Xiaoguang Liu¹  Yuping Li¹  Xiaodong Wang¹  Can Tang¹  Zhengcun Yan¹  Qiang Ma¹  Hengzhu Zhang¹  Yajie Qi¹  Min Wei¹  Qingduo Wang² 

[1] Department of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, China;Department of Neurosurgery, The Yangzhou School of Clinical Medicine of Dalian Medical University, Dalian, China;

关键词: Mendelian randomization;    intracerebral hemorrhage;    psychiatric traits;    genome-wide association study;    causality;   

DOI  :  10.3389/fpsyt.2022.1049432

 received in 2022-09-20, accepted in 2022-12-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPsychiatric traits have been associated with intracerebral hemorrhage (ICH) in observational studies, although their causal relationships remain uncertain. We used Mendelian randomization analyses to infer causality between psychiatric traits and ICH.MethodsWe collected data from genome-wide association studies of ICH (n = 361,194) and eight psychiatric traits among Europeans, including mood swings (n = 451,619), major depressive disorder (n = 480,359), attention-deficit/hyperactivity disorder (n = 53,293), anxiety (n = 459,560), insomnia (n = 462,341), schizophrenia (n = 77,096), neuroticism (n = 374,323), and bipolar disorder (n = 51,710). We performed a series of bidirectional two-sample Mendelian randomization and related sensitivity analyses. A Bonferroni corrected threshold of p < 0.00625 (0.05/8) was considered to be significant, and p < 0.05 was considered suggestive of evidence for a potential association.ResultsMendelian randomization analyses revealed suggestive positive causality of mood swings on ICH (odds ratio = 1.006, 95% confidence interval = 1.001–1.012, p = 0.046), and the result was consistent after sensitivity analysis. However, major depressive disorder (p = 0.415), attention-deficit/hyperactivity disorder (p = 0.456), anxiety (p = 0.664), insomnia (p = 0.699), schizophrenia (p = 0.799), neuroticism (p = 0.140), and bipolar disorder (p = 0.443) are not significantly associated with the incidence of ICH. In the reverse Mendelian randomization analyses, no causal effects of ICH on mood swings (p = 0.565), major depressive disorder (p = 0.630), attention-deficit/hyperactivity disorder (p = 0.346), anxiety (p = 0.266), insomnia (p = 0.102), schizophrenia (p = 0.463), neuroticism (p = 0.261), or bipolar disorder (p = 0.985) were found.ConclusionOur study revealed that mood swings are suggestively causal of ICH and increase the risk of ICH. These results suggest the clinical significance of controlling mood swings for ICH prevention.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Qi, Li, Yan, Wang, Ma, Tang, Liu, Wei and Zhang.