Novel albumin-binding multifunctional probe for synergistic enhancement of FL/MR dual-modal imaging and photothermal therapy

Frontiers in Chemistry

Chemistry

Shiyi Lyu¹  Zhuyuan Ding¹  Lujing Gao¹  Yulu Ren¹  Zhu Chen¹  Enhua Xiao¹  Qiuling Liao¹  Minping Zhang¹  Cheng Yu¹  Tao Luo¹  Huiwen Tan¹  Huan Liu¹  Linan Hu²  Pengfei Xu³ 

[1] Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China;Translational Pharmaceutical Laboratory, Jining First People’s Hospital, Shandong First Medical University, Jining, China;Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, China;

关键词: drug delivery;    albumin;    fluorescence imaging;    MRI;    photothermal therapy;   

DOI  :  10.3389/fchem.2023.1253379

 received in 2023-07-05, accepted in 2023-07-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

The fluorescence/magnetic resonance (FL/MR) dual-modal imaging could provide accurate tumor visualization to guide photothermal therapy (PTT) of cancer, which has attracted widespread attention from scientists. However, facile and effective strategies to synergistically enhance fluorescence intensity, MR contrast and photothermal efficacy have rarely been reported. This study presents a novel multifunctional probe Gd-EB-ICG (GI) for FL/MR dual-modal imaging-guided PTT of cancer. GIs can self-assemble with endogenous albumin to form drug-albumin complexes (GIAs), which exhibit excellent biocompatibility. Albumin can protect GIAs from the recognition and clearance by the mononuclear phagocytic system (MPS). High plasma concentration and long half-life allow GIAs to accumulate continuously in the tumor area through EPR effect and specific uptake of tumor. Because of the prolonged rotational correlation time (τR) of Gd chelates, GIAs exhibited superior MR contrast performance over GIs with more than 3 times enhancement of longitudinal relaxation efficiency (r1). The fluorescence quantum yield and photothermal conversion efficiency of GIAs was also significantly improved due to the constrained geometry, disrupted aggregation and enhanced photothermal stability. This simple and feasible strategy successfully resulted in a synergistic effect for FL/MR dual-modal imaging and photothermal therapy, which can cast a new light for the clinical translation of multifunctional probes.

【 授权许可】

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Copyright © 2023 Yu, Ding, Liu, Ren, Zhang, Liao, Luo, Gao, Lyu, Tan, Hu, Chen, Xu and Xiao.