Functional septorhinoplasty alters brain structure and function: Neuroanatomical correlates of olfactory dysfunction

Frontiers in Allergy

Allergy

Thomas Hummel¹  Laura Mancini²  Tarek Yousry²  Katherine L. Whitcroft³  Peter J. Andrews⁴ 

[1] Department of Otorhinolaryngology, TU Dresden, Dresden, Germany;Lysholm Department of Neuroradiology, the National Hospital for Neurology & Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom;Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom;UCL Ear Institute, University College London, London, United Kingdom;Centre for the Study of the Senses, Institute of Philosophy, School of Advanced Study, University of London, London, United Kingdom;Department of Rhinology and Facial Plastics, Royal National Throat Nose and Ear Hospital, London, United Kingdom;Department of Otorhinolaryngology, TU Dresden, Dresden, Germany;UCL Ear Institute, University College London, London, United Kingdom;Department of Rhinology and Facial Plastics, Royal National Throat Nose and Ear Hospital, London, United Kingdom;

关键词: olfaction;    olfactory dysfunction;    grey matter volume;    cortical thickness;    functional MRI;    plasticity;    treatment;    septorhinoplasty;   

DOI  :  10.3389/falgy.2023.1079945

 received in 2022-10-25, accepted in 2023-02-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionWe previously demonstrated functionally significant structural plasticity within the central olfactory networks, in association with improved olfaction after surgical treatment of chronic rhinosinusitis (CRS). In order to confirm and expand on these findings, the primary aim of this study was to determine whether these same regions undergo functionally significant structural plasticity following functional septorhinoplasty (fSRP), in patients with non-CRS olfactory dysfunction (OD) of mixed cause. fSRP has previously been shown to improve olfactory function, and the secondary aim of this study was to provide initial insights into the mechanism by which fSRP affects olfaction.MethodsWe performed a pilot prospective, multimodal neuroimaging study in 20 participants undergoing fSRP, including patients with non-CRS OD of mixed cause, as well as normosmic surgical controls. Participants underwent psychophysical olfactory testing, assessment of nasal airway, structural and functional neuroimaging. This was performed pre- and postoperatively in patients, and preoperatively in controls.ResultsThere was a statistically and clinically significant improvement in mean psychophysical olfactory scores after surgery. This was associated with structural and functional plasticity within areas of the central olfactory network (anterior cingulate, orbitofrontal cortex, insula, temporal pole). Improved psychophysical scores were significantly correlated with change in bilateral measures of nasal airflow, not measures of airflow symmetry, suggesting that improved overall airflow was more important than correction of septal deviation.ConclusionThis work highlights the importance of these neuroanatomical regions as potential structural correlates of olfactory function and dysfunction. Our results also provide initial insight into the mechanistic effects of fSRP on olfaction. Further work could investigate the utility of these regions as personalised biomarkers of OD, as well as the role of fSRP in treating OD.

【 授权许可】

Unknown   
© 2023 Whitcroft, Mancini, Yousry, Hummel and Andrews.