Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

Frontiers in Endocrinology

Endocrinology

Viacheslav O. Nikolaev¹  Sanika Mohagaonkar¹  Stepan Gambaryan² 

[1] Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany;Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia;

关键词: cAMP;    cGMP;    phosphodiesterase;    renin;    aldosterone;   

DOI  :  10.3389/fendo.2023.1239492

 received in 2023-06-13, accepted in 2023-08-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention.

【 授权许可】

Unknown   
Copyright © 2023 Gambaryan, Mohagaonkar and Nikolaev