The impact of microbially modified metabolites associated with obesity and bariatric surgery on antitumor immunity

Frontiers in Immunology

Immunology

Yuhong Huang¹  Jingda Li¹  Yanfei Zheng²  Lingru Li²  Yini Fang³  Tianxing Li⁴  Xueke Wang⁵  Meiling Xin⁶  Tianqi Cai⁶  Chao Wang⁶  Xinhua Song⁶  Ling Dong⁶  Zhengbao Xu⁶  Shufei Liang⁶  Wenlong Sun⁶  Xiaoxue Xu⁶  Meng Wang⁷ 

[1] College of Life Science, Yangtze University, Jingzhou, Hubei, China;National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China;National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China;Basic Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China;National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China;Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China;National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China;The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China;School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong, China;School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong, China;National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China;

关键词: obesity;    bariatric surgery;    cancer;    metabolites;    anti-tumor immunity;   

DOI  :  10.3389/fimmu.2023.1156471

 received in 2023-02-01, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Obesity is strongly associated with the occurrence and development of many types of cancers. Patients with obesity and cancer present with features of a disordered gut microbiota and metabolism, which may inhibit the physiological immune response to tumors and possibly damage immune cells in the tumor microenvironment. In recent years, bariatric surgery has become increasingly common and is recognized as an effective strategy for long-term weight loss; furthermore, bariatric surgery can induce favorable changes in the gut microbiota. Some studies have found that microbial metabolites, such as short-chain fatty acids (SCFAs), inosine bile acids and spermidine, play an important role in anticancer immunity. In this review, we describe the changes in microbial metabolites initiated by bariatric surgery and discuss the effects of these metabolites on anticancer immunity. This review attempts to clarify the relationship between alterations in microbial metabolites due to bariatric surgery and the effectiveness of cancer treatment. Furthermore, this review seeks to provide strategies for the development of microbial metabolites mimicking the benefits of bariatric surgery with the aim of improving therapeutic outcomes in cancer patients who have not received bariatric surgery.

【 授权许可】

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Copyright © 2023 Wang, Huang, Xin, Li, Wang, Fang, Liang, Cai, Xu, Dong, Wang, Xu, Song, Li, Zheng, Sun and Li