Recent advances in tendon tissue engineering strategy

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Zhiyao Liao¹  Han Yin¹  Shuyun Liu¹  Muzhe Li¹  Liwei Fu¹  Guangzhao Tian¹  Xiang Sui¹  Pinxue Li¹  Chao Ning²  Cangjian Gao²  Quanyi Guo²  Zhiguo Yuan³ 

[1] Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China;Chinese PLA Medical School, Beijing, China;Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China;Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China;

关键词: tendon tissue engineering;    biomaterial scaffolds;    cells, biological adjuncts;    mechanical stimuli;    macrophage polarization;   

DOI  :  10.3389/fbioe.2023.1115312

 received in 2022-12-03, accepted in 2023-02-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tendon injuries often result in significant pain and disability and impose severe clinical and financial burdens on our society. Despite considerable achievements in the field of regenerative medicine in the past several decades, effective treatments remain a challenge due to the limited natural healing capacity of tendons caused by poor cell density and vascularization. The development of tissue engineering has provided more promising results in regenerating tendon-like tissues with compositional, structural and functional characteristics comparable to those of native tendon tissues. Tissue engineering is the discipline of regenerative medicine that aims to restore the physiological functions of tissues by using a combination of cells and materials, as well as suitable biochemical and physicochemical factors. In this review, following a discussion of tendon structure, injury and healing, we aim to elucidate the current strategies (biomaterials, scaffold fabrication techniques, cells, biological adjuncts, mechanical loading and bioreactors, and the role of macrophage polarization in tendon regeneration), challenges and future directions in the field of tendon tissue engineering.

【 授权许可】

Unknown   
Copyright © 2023 Ning, Li, Gao, Fu, Liao, Tian, Yin, Li, Sui, Yuan, Liu and Guo.