An elevated likelihood of stroke, ischemic heart disease, or heart failure in individuals with gout: a longitudinal follow-up study utilizing the National Health Information database in Korea

Frontiers in Endocrinology

Endocrinology

Joo-Hee Kim¹  Ji Hee Kim²  Joo Yeon Lee³  Sung Uk Baek³  Hyo Geun Choi⁴  Ha Young Park⁵  Mi Jung Kwon⁶  Seong-Jin Cho⁷  Eun Sook Nam⁷  Ji Yeon Hong⁸  Ho Suk Kang⁹  Hyun Lim⁹  Dae Myoung Yoo^1,10  Na-Eun Lee^1,10  Kyeong Min Han^1,10  Nan Young Kim^1,11 

[1] Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea;Department of Neurosurgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea;Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea;Department of Otorhinolaryngology, Suseo Seoul E.N.T. Clinic, Seoul, Republic of Korea;MD Analytics, Seoul, Republic of Korea;Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea;Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea;Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea;Division of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea;Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea;Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea;Hallym Institute of Translational Genomics and Bioinformatics, Hallym University Medical Center, Anyang, Republic of Korea;

关键词: gout;    stroke;    ischemic heart disease;    heart failure;    cardiovascular diseases;    longitudinal follow-up study;    nationwide health insurance research database;   

DOI  :  10.3389/fendo.2023.1195888

 received in 2023-03-29, accepted in 2023-07-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveAccumulating evidence from other countries indicates potential associations between gout and cardiovascular diseases; however, the associations of gout with cardiovascular diseases, particularly stroke, ischemic heart disease, and heart failure, remain ambiguous in the Korean population. We hypothesized that individuals with gout are at a higher likelihood of stroke, ischemic heart disease, or heart failure. This study expands upon previous research by ensuring a comparable baseline between patient and control groups and analyzing 16 years of data derived from an extensive healthcare database.MethodsWe selected 22,480 patients with gout and 22,480 control individuals from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2019), and matched them at a 1:1 ratio according to sex, age, income, and residence. A Cox proportional hazard model with weighted overlap was employed to examine the relationship between gout and the risk of stroke, ischemic heart disease, or heart failure after adjustment for several covariates.ResultsThe incidences of stroke, ischemic heart disease, or heart failure in participants with gout were slightly higher than those in controls (stroke: 9.84 vs. 8.41 per 1000 person-years; ischemic heart disease: 9.77 vs. 7.15 per 1000 person-years; heart failure: 2.47 vs. 1.46 per 1000 person-years). After adjustment, the gout group had an 11% (95% confidence interval [CI] = 1.04–1.19), 28% (95% CI = 1.19–1.37), or 64% (95% CI = 1.41–1.91) higher likelihood of experiencing stroke, ischemic heart disease, or heart failure, respectively, than the control group.ConclusionThe present findings suggest that individuals with gout in the Korean population, particularly those aged ≥ 60 years, were more likely to have stroke, ischemic heart disease, or heart failure.

【 授权许可】

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Copyright © 2023 Kang, Lee, Yoo, Han, Hong, Choi, Lim, Kim, Kim, Cho, Nam, Park, Kim, Baek, Lee and Kwon