Mechanisms of immune evasion of monkeypox virus

Frontiers in Microbiology

Microbiology

Fatemeh Hosseini¹  Maryam Shafaati²  Milad Zandi³ 

[1] Department of Applied Cell Sciences, School of Advanced Technologies on Medicine, Tehran University of Medical Sciences, Tehran, Iran;Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies on Medicine, Tehran University of Medical Sciences, Tehran, Iran;Department of Microbiology, Faculty Science, Jahrom Branch, Islamic Azad University, Jahrom, Iran;Occupational Sleep Research, Baharloo Hospital, Tehran University of Medical Science, Tehran, Iran;Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;

关键词: mpox;    immune evasion;    emerging viral disease;    poxviridae;    immune system;   

DOI  :  10.3389/fmicb.2023.1106247

 received in 2022-11-23, accepted in 2023-01-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

The mpox (disease caused by the monkeypox virus) epidemic in 2022 provides a good opportunity to study the immune response to mpox. Vaccinia virus-infected monocytes could be recognized by monkeypox virus-specific CD4+ and CD8+ T cells, which produce inflammatory cytokines including IFNγ and TNFα. However, these cells are mostly unable to react to monkeypox virus-infected cells. The monkeypox virus also has no effect on the expression of MHC classes. Cells infected with monkeypox virus can prevent T cells from being activated via their T cell receptors. Insensitivity is an MHC-independent strategy for controlling antiviral T cells activation and inflammatory cytokines production. It is likely a critical aspect of virus spread in the infected host. The ability of monkeypox virus to spread efficiently as cell-associated viremia may be explained by the evasion strategies employed by the virus to subvert immunological surveillance by virus-specific T cells.

【 授权许可】

Unknown   
Copyright © 2023 Zandi, Shafaati and Hosseini.