Phage-based peptides for pancreatic cancer diagnosis and treatment: alternative approach

Frontiers in Microbiology

Microbiology

Jun-feng Ye¹  Kai-di Yang¹  Hao-yu Duan¹  Ya-nan Du¹  Yang Li¹ 

[1] General Surgery Center, First Hospital of Jilin University, Changchun, China;School of Nursing, Jilin University, Changchun, China;

关键词: pancreatic cancer;    phage display;    peptide therapy;    cancer targeting;    early detection;   

DOI  :  10.3389/fmicb.2023.1231503

 received in 2023-05-30, accepted in 2023-07-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Pancreatic cancer is a devastating disease with a high mortality rate and a lack of effective therapies. The challenges associated with early detection and the highly aggressive nature of pancreatic cancer have limited treatment options, underscoring the urgent need for better disease-modifying therapies. Peptide-based biotherapeutics have become an attractive area of research due to their favorable properties such as high selectivity and affinity, chemical modifiability, good tissue permeability, and easy metabolism and excretion. Phage display, a powerful technique for identifying peptides with high affinity and specificity for their target molecules, has emerged as a key tool in the discovery of peptide-based drugs. Phage display technology involves the use of bacteriophages to express peptide libraries, which are then screened against a target of interest to identify peptides with desired properties. This approach has shown great promise in cancer diagnosis and treatment, with potential applications in targeting cancer cells and developing new therapies. In this comprehensive review, we provide an overview of the basic biology of phage vectors, the principles of phage library construction, and various methods for binding affinity assessment. We then describe the applications of phage display in pancreatic cancer therapy, targeted drug delivery, and early detection. Despite its promising potential, there are still challenges to be addressed, such as optimizing the selection process and improving the pharmacokinetic properties of phage-based drugs. Nevertheless, phage display represents a promising approach for the development of novel targeted therapies in pancreatic cancer and other tumors.

【 授权许可】

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Copyright © 2023 Li, Yang, Duan, Du and Ye.