The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish

Frontiers in Immunology

Immunology

Ziru Gao¹  Yiju Lv¹  Yin Wang¹  Zhixia Zhou¹  Linhai Long¹  Peifeng Li¹  Zhan Wang²  Shoushi Wang²  Cuibo Leng² 

[1] Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China;The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, China;

关键词: lncRNA;    miRNA;    teleost;    reproduction;    immunity;    infection;   

DOI  :  10.3389/fimmu.2023.1065357

 received in 2022-10-09, accepted in 2023-02-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Research over the past two decades has confirmed that noncoding RNAs (ncRNAs), which are abundant in cells from yeast to vertebrates, are no longer “junk” transcripts but functional regulators that can mediate various cellular and physiological processes. The dysregulation of ncRNAs is closely related to the imbalance of cellular homeostasis and the occurrence and development of various diseases. In mammals, ncRNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The regulatory functions of lncRNAs on gene expression are usually mediated by crosstalk with miRNAs. The most predominant mode of lncRNA-miRNA crosstalk is the lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs). Compared to mammals, little attention has been given to the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species. In this review, we provide current knowledge about the teleost lncRNA-miRNA-mRNA axis, focusing on its physiological and pathological regulation in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and other stress-related immune responses. Herein, we also explored the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry. These findings contribute to an enhanced understanding of ncRNA and ncRNA-ncRNA crosstalk in fish biology to improve aquaculture productivity, fish health and quality.

【 授权许可】

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Copyright © 2023 Zhou, Leng, Wang, Long, Lv, Gao, Wang, Wang and Li