Innate-like T lymphocytes in chronic liver disease

Frontiers in Immunology

Immunology

Mihalis Verykokakis¹  Maria Papanastasatou¹ 

[1] Biomedical Sciences Research Center Alexander Fleming, Institute for Fundamental Biomedical Research, Vari, Greece;

关键词: innate-like T cells;    NAFLD;    NASH;    HCC;    chronic inflammation;   

DOI  :  10.3389/fimmu.2023.1114605

 received in 2022-12-02, accepted in 2023-02-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis. Foremost among these are innate-like T lymphocytes, including natural killer T (NKT) and mucosal-associated innate T (MAIT) cells, which are a population of specialized T cells with innate characteristics that express semi-invariant T cell receptors with non-peptide antigen specificity. As primary liver residents, innate-like T cells have been associated with immune tolerance in the liver, but also with a number of hepatic diseases. Here, we focus on the biology of NKT and MAIT cells and how they operate during the course of chronic inflammatory diseases that eventually lead to hepatocellular carcinoma.

【 授权许可】

Unknown   
Copyright © 2023 Papanastasatou and Verykokakis