Frontiers in Immunology | |
Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets | |
Immunology | |
Jiaqi Li1  Hua-Ji Qiu1  Su Li1  Yanjin Wang1  Hao Deng1  | |
[1] State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; | |
关键词: immunometabolism; innate immunity; adaptive immunity; immunoevasion; metabolic reprogramming; | |
DOI : 10.3389/fimmu.2023.1228811 | |
received in 2023-05-25, accepted in 2023-07-07, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Cellular metabolism plays a central role in the regulation of both innate and adaptive immunity. Immune cells utilize metabolic pathways to modulate the cellular differentiation or death. The intricate interplay between metabolism and immune response is critical for maintaining homeostasis and effective antiviral activities. In recent years, immunometabolism induced by viral infections has been extensively investigated, and accumulating evidence has indicated that cellular metabolism can be hijacked to facilitate viral replication. Generally, virus-induced changes in cellular metabolism lead to the reprogramming of metabolites and metabolic enzymes in different pathways (glucose, lipid, and amino acid metabolism). Metabolic reprogramming affects the function of immune cells, regulates the expression of immune molecules and determines cell fate. Therefore, it is important to explore the effector molecules with immunomodulatory properties, including metabolites, metabolic enzymes, and other immunometabolism-related molecules as the antivirals. This review summarizes the relevant advances in the field of metabolic reprogramming induced by viral infections, providing novel insights for the development of antivirals.
【 授权许可】
Unknown
Copyright © 2023 Li, Wang, Deng, Li and Qiu
【 预 览 】
Files | Size | Format | View |
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RO202310105069858ZK.pdf | 1646KB | download |