期刊论文详细信息
Frontiers in Genetics | |
Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer | |
Genetics | |
Jialin Yuan1  Hua Xing1  Huijie Xiao2  Jiannan Huang2  Yang Jiang2  Jinjing Zhai2  Rongnan Zhai2  Chaofeng Yuan2  Haitao Li3  | |
[1]Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China | |
[2]Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China | |
[3]Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China | |
关键词: gastric cancer; MMP-matrix metalloproteinase; immunogenic profile; clinical diagnosis; immunotherapy; clinical treatment; genomics; | |
DOI : 10.3389/fgene.2023.1128088 | |
received in 2022-12-20, accepted in 2023-04-04, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
This study systematically and comprehensively analyzed the characteristics of matrix metalloproteinases (MMPs) in gastric cancer (GC) and revealed the relationship between MMPs and prognoses, clinicopathological features, tumor microenvironment, gene mutations, and drug therapy response in patients with GC. Based on the mRNA expression profiles of 45 MMP-related genes in GC, we established a model that classified GC patients into three groups based on cluster analysis of the mRNA expression profiles. The 3 groups of GC patients showed significantly different prognoses as well as tumor microenvironmental characteristics. Next, we used Boruta’s algorithm and PCA method to establish an MMP scoring system and found that lower MMP scores were associated with better prognoses, lower clinical stages, better immune cell infiltration, lower degrees of immune dysfunction and rejection, and more genetic mutations. Whereas a high MMP score was the opposite. These observations were further validated with data from other datasets, showing the robustness of our MMP scoring system. Overall, MMP could be involved in the tumor microenvironment (TME), clinical features, and prognosis of GC. An in-depth study of MMP patterns can better understand the indispensable role of MMP in the development of GC and reasonably assess the survival prognosis, clinicopathological features, and drug efficacy of different patients, thus providing clinicians with a broader vision of GC progression and treatment.【 授权许可】
Unknown
Copyright © 2023 Yuan, Yuan, Xiao, Li, Jiang, Zhai, Zhai, Xing and Huang.
【 预 览 】
Files | Size | Format | View |
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RO202310105046147ZK.pdf | 3597KB | download |