Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes

Frontiers in Immunology

Immunology

Hao Chi¹  Lisa Jia Tran²  Zhijia Xia²  Gang Tian³  Songyun Zhao⁴  Fang Yang⁵  Guanhu Yang⁶  Jingwen Xiong⁷  Jing Zhang⁸ 

[1] Clinical Medical College, Southwest Medical University, Luzhou, China;Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany;Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China;Department of Neurosurgery, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, China;Department of Ophthalmology, Charité – Universitätsmedizin Berlin, Berlin, Germany;Department of Specialty Medicine, Ohio University, Athens, OH, United States;Department of Sports Rehabilitation, Southwest Medical University, Luzhou, China;Division of Basic Biomedical Sciences, The University of South Dakota Sanford School of Medicine, Vermillion, SD, United States;

关键词: B cell;    B cell-derived exosome;    therapy;    TME;    anti-tumor;   

DOI  :  10.3389/fimmu.2023.1188760

 received in 2023-03-17, accepted in 2023-05-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

B cells occupy a vital role in the functioning of the immune system, working in tandem with T cells to either suppress or promote tumor growth within the tumor microenvironment(TME). In addition to direct cell-to-cell communication, B cells and other cells release exosomes, small membrane vesicles ranging in size from 30-150 nm, that facilitate intercellular signaling. Exosome research is an important development in cancer research, as they have been shown to carry various molecules such as major histocompatibility complex(MHC) molecules and integrins, which regulate the TME. Given the close association between TME and cancer development, targeting substances within the TME has emerged as a promising strategy for cancer therapy. This review aims to present a comprehensive overview of the contributions made by B cells and exosomes to the tumor microenvironment (TME). Additionally, we delve into the potential role of B cell-derived exosomes in the progression of cancer.

【 授权许可】

Unknown   
Copyright © 2023 Xiong, Chi, Yang, Zhao, Zhang, Tran, Xia, Yang and Tian