The interplay of sex steroid hormones and microRNAs in endometrial cancer: current understanding and future directions

Frontiers in Endocrinology

Endocrinology

Lovlesh Thakur¹  Sunil Thakur² 

[1] Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India;Origin LIFE Healthcare Solutions and Research Center, Chandigarh, India;

关键词: microRNA;    endometrial cancer;    sex steroid hormones;    estrogen;    progesterone;    hormone therapy;   

DOI  :  10.3389/fendo.2023.1166948

 received in 2023-02-15, accepted in 2023-04-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionEndometrial cancer is a hormone-dependent malignancy, and sex steroid hormones play a crucial role in its pathogenesis. Recent studies have demonstrated that microRNAs (miRNAs) can regulate the expression of sex steroid hormone receptors and modulate hormone signaling pathways. Our aim is to provide an overview of the current understanding of the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways.MethodsA thorough literature search was carried out in the PubMed database. The articles published from 2018 to the present were included. Keywords related to miRNAs, endometrial cancer, and sex steroid hormones were used in the search.ResultsDysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Additionally, specific miRNAs have been implicated in the regulation of genes involved in hormone-related signaling pathways, such as the PI3K/Akt/mTOR and MAPK/ERK pathways.ConclusionThe regulation of sex steroid hormones by miRNAs is a promising area of research in endometrial cancer. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.

【 授权许可】

Unknown   
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