Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Chengzhi Gui¹  Yiying Song²  Qingqing Xian²  Yunying Zhou³ 

[1] Department of Clinical Laboratory Diagnosis, Shandong First Medical University, Jinan, Shandong, China;Department of Clinical Laboratory Diagnosis, Shandong University, Jinan, Shandong, China;Department of Clinical Laboratory Diagnosis, Shandong University, Jinan, Shandong, China;Department of Clinical Laboratory Diagnosis, Shandong First Medical University, Jinan, Shandong, China;Medical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China;

关键词: YEATS4;    oncogene;    tumorigenesis;    signaling pathway;    regulatory mechanism;   

DOI  :  10.3389/fcell.2023.1192139

 received in 2023-03-23, accepted in 2023-06-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

As a novel oncogene, the role of YEATS domain-containing protein 4 (YEATS4) in the occurrence, development, and treatment of tumors is now beginning to be appreciated. YEATS4 plays an important role in regulating DNA repair during replication. The upregulation of YEAST4 promotes DNA damage repair and prevents cell death, whereas its downregulation inhibits DNA replication and induces apoptosis. Additionally, accumulating evidence indicates that the aberrant activation of YEATS4 leads to changes in drug resistance, epithelial-mesenchymal transition and also in the migration and invasion capacity of tumor cells. Therefore, specific inhibition of the expression or activity of YEATS4 protein may be an effective strategy for inhibiting the proliferation, motility, differentiation, and/or survival of tumor cells. Taken together, YEATS4 has emerged as a potential target for multiple cancers and is an attractive protein for the development of small-molecule inhibitors. However, research on YEAST4 in tumor-related fields is limited and its biological functions, metabolism, and the regulatory mechanism of YEATS4 in numerous cancers remain undetermined. This review comprehensively and extensively summarizes the functions, structure and oncogenic roles of YEATS4 in cancer progression and aims to further contribute to the study of its underlying molecular mechanism and targeted drugs.

【 授权许可】

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Copyright © 2023 Xian, Song, Gui and Zhou.