Nitric oxide synthase 2 genetic variation rs2297514 associates with a decreased susceptibility to extremity post-traumatic osteomyelitis in a Chinese Han population

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Chun-qiu Pan¹  Yan-jun Hu²  Ping Zhang²  Qing-rong Lin²  Ying-yu Hu³  Chen-sheng Song⁴  Nan Jiang⁴ 

[1] Department of Emergency Trauma Center, Nanfang Hospital, Southern Medical University, Guangzhou, China;Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China;Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China;Department of Hospital Management, Southern Medical University, Guangzhou, China;Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China;Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China;

关键词: post-traumatic osteomyelitis;    fracture-related infection;    Nos2;    single nucleotide polymorphisms;    rs2297514;    case-control study;   

DOI  :  10.3389/fcimb.2023.1177830

 received in 2023-03-02, accepted in 2023-06-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPrevious studies have indicated that nitric oxide synthase 2 (NOS2) genetic variations are involved in delayed fracture healing and fracture non-union. Whether these genetic variants associate with the development of osteomyelitis (OM) remains unclear. Here, we analyzed the potential relationships between NOS2 genetic variations and the risk of developing post-traumatic OM (PTOM) in a Chinese Han population.MethodsAltogether 704 participants, including 336 PTOM patients and 368 healthy controls, were genotyped of rs2297514 and rs2248814 of the NOS2 gene using the SNaPshot genotyping method. ResultsOutcomes showed that the frequency of allele C of rs2297514 in the patient group was significantly lower than that in the control group (48.7% vs. 54.5%, P = 0.029, OR = 0.792, 95% CI 0.642 – 0.976). In addition, significant associations were found between rs2297514 and susceptibility to PTOM by the recessive model (P = 0.007, OR = 0.633, 95% CI 0.453 – 0.884), and the homozygous model (P = 0.039, OR = 0.648, 95% CI 0.429 – 0.979). Moreover, patients with the CC genotype of rs2297514 had lower inflammatory biomarkers levels than the TT genotype, especially for the C-reactive protein (CRP) level (median: 4.1 mg/L vs. 8.9 mg/L, P = 0.027). However, no significant relationship was noted between rs2248814 and the risk of developing PTOM.ConclusionIn this Chinese cohort, rs2297514 is correlated with a decreased risk of PTOM development, with genotype CC as a protective factor.

【 授权许可】

Unknown   
Copyright © 2023 Song, Zhang, Lin, Hu, Pan, Jiang and Hu