Effects of ketogenic diet on the classification and functional composition of intestinal flora in children with mitochondrial epilepsy

Frontiers in Neurology

Neurology

Weijie He¹  Hua Li²  Fang Fang³  Xu Wang⁴  Hong Han⁵  Guohong Chen⁶  Liming Yang⁷  Guo Zheng⁸  Jianxiang Liao⁹  Jianmin Liang^1,10  Dong Wang^1,11  Dan Sun^1,12  Jing Wang^1,12  LIjuan Huang^1,12 

[1] Aegicare (Shenzhen) Technology Co., Ltd., Shenzhen, China;Department of Epilepsy Center, Guangdong 999 Brain Hospital, Guangzhou, China;Department of Neurology, Beijing Children’s Hospital, Capital Medical University, Beijing, China;Department of Neurology, Changchun Children’s Hospital, Changchun, China;Department of Neurology, Children’s Hospital of Shanxi, Taiyuan, China;Department of Neurology, Henan Provincial Children’s Hospital, Zhengzhou, China;Department of Neurology, Hunan Provincial Children’s Hospital, Changsha, China;Department of Neurology, Nanjing Children’s Hospital, Nanjing, China;Department of Neurology, Shenzhen Children’s Hospital, Shenzhen, China;Department of Neurology, The First Bethune Hospital of Jilin University, Changchun, China;Department of Neurology, Xi’an Children’s Hospital, Xi’an, China;Department of Pediatric Neurology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;

关键词: mitochondrial epilepsy;    ketogenic diet;    gut microbiota;    microbiota-gut-brain axis;    Bacteroides fragilis;   

DOI  :  10.3389/fneur.2023.1237255

 received in 2023-06-09, accepted in 2023-07-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

The ketogenic diet (KD) has shown excellent performance in the treatment of refractory epilepsy, but how it works is not yet fully understood. Gut microbiota is associated with various neurological disorders through the brain-gut axis. Different dietary patterns have different effects on the composition and function of gut microbiota. Here, by analyzing fecal samples from some patients with mitochondrial epilepsy before and after KD treatment through 16SrRNA sequencing, we found that KD intervention reduced the abundance of Firmicutes in the patient’s gut, while the abundance of Bacteroidota increased in the KD group. LefSe analysis showed that Actinobacteriota, Phascolarctobacterium had significant advantages in the control group, while Bacteroides increased significantly after KD intervention, especially Bacteroides fragilis. Functional analysis showed that there were significant differences in 12 pathways in level 3. These changes suggest that KD can change the composition and diversity of the gut microbiota in patients and affect their function. Changes in specific bacterial groups in the gut may serve as biomarkers for the therapeutic effects of KD on epilepsy.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Huang, Li, Chen, Yang, Wang, Han, Zheng, Wang, Liang, He, Fang, Liao and Sun.