Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders

Frontiers in Cellular Neuroscience

Neuroscience

Shunyu Yu¹  Mengqian Li¹  Yiran Wang² 

[1] Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, China;

关键词: autism spectrum disorder (ASD);    cerebrovascular;    blood-brain barrier;    neurovascular unit;    neurovascular crosstalk;   

DOI  :  10.3389/fncel.2023.1226580

 received in 2023-05-21, accepted in 2023-08-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

Normal brain development, function, and aging critically depend on unique characteristics of the cerebrovascular system. Growing evidence indicated that cerebrovascular defects can have irreversible effects on the brain, and these defects have been implicated in various neurological disorders, including autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder with heterogeneous clinical manifestations and anatomical changes. While extensive research has focused on the neural abnormalities underlying ASD, the role of brain vasculature in this disorder remains poorly understood. Indeed, the significance of cerebrovascular contributions to ASD has been consistently underestimated. In this work, we discuss the neurovascular crosstalk during embryonic development and highlight recent findings on cerebrovascular alterations in individuals with ASD. We also discuss the potential of vascular-based therapy for ASD. Collectively, these investigations demonstrate that ASD can be considered a neurovascular disease.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Yu and Li.