Non-invasive brain stimulation for treating catatonia: a systematic review

Frontiers in Psychiatry

Psychiatry

Gaoju Deng¹  Shiyu Liu¹  Huan Sun¹  Mei Wang¹  Hongqi Xiao¹  Yaozong Zheng¹  Changjian Qiu¹  Yajing Meng¹  Yuan Cao² 

[1] Mental Health Center, West China Hospital of Sichuan University, Chengdu, China;Sichuan Clinical Medical Research Center for Mental Disorders, Chengdu, China;Mental Health Center, West China Hospital of Sichuan University, Chengdu, China;Sichuan Clinical Medical Research Center for Mental Disorders, Chengdu, China;Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China;Department of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China;

关键词: non-invasive brain stimulation;    catatonia;    electroconvulsive therapy;    repetitive transcranial magnetic stimulation;    transcranial direct current stimulation;   

DOI  :  10.3389/fpsyt.2023.1135583

 received in 2023-01-01, accepted in 2023-04-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundNon-invasive brain stimulation (NIBS) techniques offer new therapeutic options for modifying pathological neuroplasticity and have been proven to be beneficial in the treatment of neuropsychiatric disorders.ObjectiveThis study aimed to investigate the role of NIBS in treating catatonia.Materials and methodsWe conducted a systematic search to identify meta-analyses or systematic reviews on electroconvulsive therapy (ECT) and studies on the effects of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) on patients with catatonia from the PubMed, Web of Science, Embase, China National Knowledge Internet, Wanfang, and China Science and Technology Journal databases from inception until 31 July 2022. The methodological quality of the included studies was assessed with the AMSTAR2 or Joanna Briggs Institute Critical Appraisal tools. Paired t-tests and Wilcoxon signed-rank tests were used to compare changes in catatonia symptom scores after rTMS or tDCS.ResultsA total of 13 systematic reviews and one meta-analysis on ECT, two systematic reviews and 12 case reports on rTMS, and seven studies of 14 cases applying tDCS were identified. Systematic reviews of ECT consistently described improvement in catatonia symptoms across catatonia types and patient age groups. After treatment with rTMS (t = 4.489, p = 0.006) and tDCS (z = −3.065, p = 0.002), patients exhibited significant improvement.ConclusionECT, rTMS, and tDCS were effective in treating catatonia. Early intervention with NIBS techniques may help improve catatonia symptoms in patients with schizophrenia. It may be advantageous to use rTMS or tDCS to maintain this improvement. NIBS techniques may thus represent a promising treatment for catatonia, but additional high-quality randomized controlled trials are needed.

【 授权许可】

Unknown   
Copyright © 2023 Xiao, Meng, Liu, Cao, Sun, Deng, Wang, Zheng and Qiu.