Esophageal microflora in esophageal diseases

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Qian Zou¹  Lijuan Feng¹  Yun Qian¹  Long Xu¹  Xunchao Cai¹ 

[1] Department of Gastroenterology and Hepatology, Shenzhen University General Hospital, Shenzhen, China;

关键词: esophageal diseases;    microbiota;    gastroesophageal reflux;    Barrett’s esophagus;    eosinophilic esophagitis;    esophageal cancer;   

DOI  :  10.3389/fcimb.2023.1145791

 received in 2023-01-16, accepted in 2023-05-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

With the development of endoscopic technology, an increasing number of patients with esophageal disease are being diagnosed, although the underlying pathogenesis of many esophageal diseases remains unclear. In recent years, a large number of studies have demonstrated that the occurrence and development of various intestinal diseases were related to intestinal flora. As a result, researchers have shifted their focus towards investigating esophageal flora to better understand the pathogenesis, early diagnosis, and treatment of esophageal diseases. This paper reviewed the normal esophageal flora and the changes of esophageal flora under different esophageal disease states. It was observed that there are distinct differences in the composition of esophageal microflora among Gastroesophageal Reflux, Barrett’s esophagus, eosinophilic esophagitis and normal esophagus. The normal esophageal flora was dominated by gram-positive bacteria, particularly Streptococcus, while the esophageal flora under esophagitis was dominated by gram-negative bacteria. Furthermore, the diversity of esophageal flora is significantly decreased in patients with esophageal cancer. Several potential microbial biomarkers for esophageal cancer have been identified, among which Fusobacterium nucleatum showed a close association with esophageal squamous cell carcinoma’s pathological stage and clinical stage.

【 授权许可】

Unknown   
Copyright © 2023 Zou, Feng, Cai, Qian and Xu