Skin immunity in wound healing and cancer

Frontiers in Immunology

Immunology

Tatyana Chtanova¹  Arnolda Jakovija² 

[1] Immunity Theme, Garvan Institute of Medical Research, Sydney, Australia;School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, Australia;Immunity Theme, Garvan Institute of Medical Research, Sydney, Australia;St. Vincent’s School of Medicine, Faculty of Medicine, University of New South Wales, Sydney, Australia;

关键词: skin wound healing;    skin immunity;    innate response;    skin cancer immunity;    skin adaptive immunity;   

DOI  :  10.3389/fimmu.2023.1060258

 received in 2022-10-03, accepted in 2023-05-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

The skin is the body’s largest organ. It serves as a barrier to pathogen entry and the first site of immune defense. In the event of a skin injury, a cascade of events including inflammation, new tissue formation and tissue remodeling contributes to wound repair. Skin-resident and recruited immune cells work together with non-immune cells to clear invading pathogens and debris, and guide the regeneration of damaged host tissues. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds. This, in turn, can promote skin tumorigenesis. Tumors appropriate the wound healing response as a way of enhancing their survival and growth. Here we review the role of resident and skin-infiltrating immune cells in wound repair and discuss their functions in regulating both inflammation and development of skin cancers.

【 授权许可】

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