Transplacental passage of hyperforin, hypericin, and valerenic acid

Frontiers in Pharmacology

Pharmacology

Sabrina Kuoni¹  Ana Paula Simões-Wüst¹  Joshua Rath¹  Deborah Spiess²  Michael Reinehr³  Andrea Treyer⁴  Mouhssin Oufir⁴  Olivier Potterat⁴  Matthias Hamburger⁴  Antoine Chauveau⁴  Vanessa Fabienne Abegg⁴ 

[1] Department of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland;Department of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland;Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland;Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland;Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland;

关键词: hyperforin;    hypericin;    valerenic acid;    Hypericum perforatum;    Valeriana officinalis;    placental perfusion;    pregnancy;    U(H)PLC-MS/MS;   

DOI  :  10.3389/fphar.2023.1123194

 received in 2022-12-13, accepted in 2023-03-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Safe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John’s wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St. John’s wort), and valerenic acid (from valerian) was evaluated using the ex vivo cotyledon perfusion model (4 h perfusions, term placentae) and, in part, the in vitro Transwell assay with BeWo b30 cells. Antipyrine was used for comparison in both models. U(H)PLC-MS/MS bioanalytical methods were developed to quantify the compounds. Perfusion data obtained with term placentae showed that only minor amounts of hyperforin passed into the fetal circuit, while hypericin did not cross the placental barrier and valerenic acid equilibrated between the maternal and fetal compartments. None of the investigated compounds affected metabolic, functional, and histopathological parameters of the placenta during the perfusion experiments. Data from the Transwell model suggested that valerenic acid does not cross the placental cell layer. Taken together, our data suggest that throughout the pregnancy the potential fetal exposure to hypericin and hyperforin – but not to valerenic acid – is likely to be minimal.

【 授权许可】

Unknown   
Copyright © 2023 Spiess, Abegg, Chauveau, Rath, Treyer, Reinehr, Kuoni, Oufir, Potterat, Hamburger and Simões-Wüst.