Survival differences between women and men in the non-reproductive cancers: Results from a matched analysis of the surveillance, epidemiology, and end-results program

Frontiers in Public Health

Public Health

Pollyana Júnia Felicidade¹  Camila Piqui Nascimento¹  Eduarda da Costa Marinho¹  Rafael Mathias Antonioli¹  Felipe Andrés Cordero da Luz²  Rogério Agenor de Araújo³  Marcelo José Barbosa Silva⁴ 

[1] Center for Cancer Prevention and Research, Uberlandia Cancer Hospital, Umuarama, Uberlândia, Minas Gerais, Brazil;Center for Cancer Prevention and Research, Uberlandia Cancer Hospital, Umuarama, Uberlândia, Minas Gerais, Brazil;Laboratory of Tumor Biomarkers and Osteoimmunology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlandia, Umuarama, Uberlândia, Minas Gerais, Brazil;Center for Cancer Prevention and Research, Uberlandia Cancer Hospital, Umuarama, Uberlândia, Minas Gerais, Brazil;Laboratory of Tumor Biomarkers and Osteoimmunology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlandia, Umuarama, Uberlândia, Minas Gerais, Brazil;Medical Faculty, Federal University of Uberlandia, Umuarama, Uberlândia, Minas Gerais, Brazil;Laboratory of Tumor Biomarkers and Osteoimmunology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlandia, Umuarama, Uberlândia, Minas Gerais, Brazil;

关键词: solid cancer;    sex;    survival;    cancer prevalence;    non-reproductive cancer;   

DOI  :  10.3389/fpubh.2022.1076682

 received in 2022-10-21, accepted in 2022-12-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundMen with non-reproductive cancers have a discrepant outcome compared to women. However, they differ significantly in the incidence of cancer type and characteristics.MethodsPatients with single primary cancer who were 18 years or older and whose data were gathered and made accessible by the Surveillance, Epidemiology, and End Results (SEER) program were included in this retrospective analysis. Kaplan-Meier curves and Cox regression before and after propensity score matching were performed to analyze the risk survival by sex.ResultsAmong the 1,274,118 patients included [median (range) age, 65 year (18–85+) years; 688,481 (54.9%) male]. The median follow-up was 21 months (0–191). Substantial improvements in survival were observed for both sexes during the years of inclusion analyzed, with no difference between them, reaching a reduction of almost 17% of deaths in 2010, and of almost 28% in 2015, compared to 2004. The women had a median survival of 74 months and overall mortality of 48.7%. Males had a median survival of 30 months (29.67–30.33) with an overall mortality of 56.2%. The PSM showed a reduced difference (6 months shorter median survival and 2.3% more death in men), but no change in hazards was observed compared to the unmatched analysis [adjusted HR: 0.888 (0.864–0.912) vs. 0.876 (0.866–0.886) in unmatched].ConclusionsThe discrepancy in survival between men and women is not explained only by the incidence of more aggressive and more advanced cancers in the former.

【 授权许可】

Unknown   
Copyright © 2023 Luz, Nascimento, Marinho, Felicidade, Antonioli, Araújo and Silva.