Histone deacetylase functions and therapeutic implications for adult skeletal muscle metabolism

Frontiers in Molecular Biosciences

Molecular Biosciences

Alessandra Renzini¹  Carol Imbriano²  Susanna Molinari²  Silvia Belluti²  Biliana Lozanoska-Ochser³  Viviana Moresi⁴  Alessia Cedola⁴  Giuseppe Gigli⁵ 

[1] DAHFMO Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy;Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy;Department of Medicine and Surgery, LUM University, Casamassima, Italy;Institute of Nanotechnology, Department of Physics, National Research Council (CNR-NANOTEC), Sapienza University of Rome, Rome, Italy;Institute of Nanotechnology, National Research Council (CNR-NANOTEC), Lecce, Italy;

关键词: HDACs;    sarcopenia;    type 2 diabetes;    neurogenic muscle atrophy;    sirtuins;    glucose uptake;    fatty acid oxidation;    metabolic flexibility;   

DOI  :  10.3389/fmolb.2023.1130183

 received in 2022-12-22, accepted in 2023-03-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Skeletal muscle is a highly adaptive organ that sustains continuous metabolic changes in response to different functional demands. Healthy skeletal muscle can adjust fuel utilization to the intensity of muscle activity, the availability of nutrients and the intrinsic characteristics of muscle fibers. This property is defined as metabolic flexibility. Importantly, impaired metabolic flexibility has been associated with, and likely contributes to the onset and progression of numerous pathologies, including sarcopenia and type 2 diabetes. Numerous studies involving genetic and pharmacological manipulations of histone deacetylases (HDACs) in vitro and in vivo have elucidated their multiple functions in regulating adult skeletal muscle metabolism and adaptation. Here, we briefly review HDAC classification and skeletal muscle metabolism in physiological conditions and upon metabolic stimuli. We then discuss HDAC functions in regulating skeletal muscle metabolism at baseline and following exercise. Finally, we give an overview of the literature regarding the activity of HDACs in skeletal muscle aging and their potential as therapeutic targets for the treatment of insulin resistance.

【 授权许可】

Unknown   
Copyright © 2023 Molinari, Imbriano, Moresi, Renzini, Belluti, Lozanoska-Ochser, Gigli and Cedola.