HMGB1: a double-edged sword and therapeutic target in the female reproductive system

Frontiers in Immunology

Immunology

Zhaolian Wei¹  Xingxing Han¹  Ping Zhou¹  Qiqi Zhang¹  Damin Zhu¹  Beili Chen¹  Yunxia Cao²  Yu Ren²  Huijuan Zou²  Zhiguo Zhang² 

[1] Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;Anhui Key Laboratory of Reproductive Health and Genetics, Anhui Medical University, Hefei, Anhui, China;Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, Anhui, China;Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;National Health Commission (NHC) Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, China;Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China;

关键词: HMGB1;    pregnancy complications;    female reproductive system diseases;    inflammation;    anti-HMGB1;   

DOI  :  10.3389/fimmu.2023.1238785

 received in 2023-06-12, accepted in 2023-08-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin associated transcription factor. It is present in the nucleus of eukaryotes and can be actively secreted or passively released by kinds of cells. HMGB1 is important for maintaining DNA structure by binding to DNA and histones, protecting it from damage. It also regulates the interaction between histones and DNA, affecting chromatin packaging, and can influence gene expression by promoting nucleosome sliding. And as a DAMP, HMGB1 binding to RAGE and TLRs activates NF-κB, which triggers the expression of downstream genes like IL-18, IL-1β, and TNF-α. HMGB1 is known to be involved in numerous physiological and pathological processes. Recent studies have demonstrated the significance of HMGB1 as DAMPs in the female reproductive system. These findings have shed light on the potential role of HMGB1 in the pathogenesis of diseases in female reproductive system and the possibilities of HMGB1-targeted therapies for treating them. Such therapies can help reduce inflammation and metabolic dysfunction and alleviate the symptoms of reproductive system diseases. Overall, the identification of HMGB1 as a key player in disease of the female reproductive system represents a significant breakthrough in our understanding of these conditions and presents exciting opportunities for the development of novel therapies.

【 授权许可】

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Copyright © 2023 Ren, Zhu, Han, Zhang, Chen, Zhou, Wei, Zhang, Cao and Zou