Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease

Frontiers in Aging Neuroscience

Neuroscience

Saleha Abdul Rab¹  Ghaith Adi¹  Ahmed Yaqinuddin¹  Khaled Hamsho¹  Mohammed Al-Rimawi¹  Khaled Alkattan¹  Mohammed Alfuwais¹  Ahmed Noor Eddin² 

[1] College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;null;

关键词: Alzheimer’s disease;    neurodegenerative disorder;    dementia;    MicroRNAs;    cerebrospinal fluid;    diagnosis;    biomarker;    neuroinflammation;   

DOI  :  10.3389/fnagi.2023.1210191

 received in 2023-04-21, accepted in 2023-06-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Alzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are a group of small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important role in the five major hallmarks of AD pathophysiology: amyloidogenesis, tauopathy, neuroinflammation, synaptic dysfunction, and neuronal death. Compared to traditional biomarkers of AD, miRNAs display a greater degree of stability in cerebrospinal fluid. Moreover, aberrant changes in miRNA expression can be measured over time to monitor and guide patient treatment. Specific miRNA profiles and combinations may also be used to distinguish AD subjects from normal controls and other causes of dementia. Because of these properties, miRNAs are now being considered as promising and potential biomarkers of AD. This review comprehensively summarizes the diagnostic potential and regulatory roles miRNAs play in AD.

【 授权许可】

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Copyright © 2023 Noor Eddin, Hamsho, Adi, Al-Rimawi, Alfuwais, Abdul Rab, Alkattan and Yaqinuddin.