A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)

Frontiers in Oncology

Oncology

Christina M. Dieli-Conwright¹  Kerryn W. Reding²  Vidhya Nair³  Sreejata Raychaudhuri⁴  Michael S. Simon⁵  Pinkal Desai⁶  Katherine L. Cook⁷  Richard K. Cheng⁸  Alexi Vasbinder⁹  Ana Barac^1,10 

[1] Dana-Faber Cancer Institute and Harvard Medical School, Boston, MA, United States;Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, WA, United States;Department of Hematology/Oncology, Ascension Providence Hospital/Michigan State University College of Human Medicine, Southfield, MI, United States;Department of Oncology, Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United States;Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI, United States;Population Studies and Disparities Research Program, Karmanos Cancer Institute, Detroit, MI, United States;Department of Oncology, Weill Cornell Medical College, New York, NY, United States;Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, United States;Division of Cardiology, University of Washington, Seattle, WA, United States;Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States;MedStar Heart and Vascular Institute, Georgetown University, Washington, DC, United States;

关键词: breast cancer;    cardiovascular disease;    cancer treatment;    risk factors;    cancer survivors;   

DOI  :  10.3389/fonc.2022.1039246

 received in 2022-09-07, accepted in 2022-11-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Both obesity and metabolic syndrome are linked to increased incidence of type 2 diabetes, cardiovascular disease (CVD), and cancers of the breast (post-menopausal), and other obesity-related cancers. Over the past 50 years, the worldwide prevalence of obesity and metabolic syndrome has increased, with a concomitant higher incidence of associated co-morbidities and mortality. The precise mechanism linking metabolic syndrome to increased cancer incidence is incompletely understood, however, individual components of metabolic syndrome have been linked to increased breast cancer incidence and worse survival. There is a bidirectional relationship between the risk of CVD and cancer due to a high burden of shared risk factors and higher rates of CVD among cancer survivors, which may be impacted by the pro-inflammatory microenvironment associated with metabolic syndrome and cancer-directed therapies. The Women’s Health Initiative (WHI) is an excellent resource to study a dual relationship between cancer and CVD (cardio-oncology) with extensive information on risk factors and long-term outcomes. The purpose of this review is to provide an overview of research on cardio-oncology conducted utilizing WHI data with focus on studies evaluating both breast cancer and CVD including shared risk factors and outcomes after cancer. The review also includes results on other obesity related cancers which were included in the analyses of breast cancer, articles looking at cancer after heart disease (reverse cardio-oncology) and the role of Clonal Hematopoiesis of Indeterminate Potential (CHIP) as a shared risk factor between CVD and cancer. A summary of pertinent WHI literature helps to delineate the direction of future research evaluating the relationship between CVD and other cancer sites, and provides information on the opportunity for other novel analyses within the WHI.

【 授权许可】

Unknown   
Copyright © 2023 Raychaudhuri, Dieli-Conwright, Cheng, Barac, Reding, Vasbinder, Cook, Nair, Desai and Simon