Extracellular vesicles in atherosclerosis and vascular calcification: the versatile non-coding RNAs from endothelial cells and vascular smooth muscle cells

Frontiers in Medicine

Medicine

Zhangxiu He¹  Fengyi Yu¹  Yingjie Duan¹  Xiangcheng Xiao²  Chongmei Liu³  Hong Huang⁴ 

[1] Department of Nephrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China;Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Pathology, Yueyang People's Hospital, Yueyang, Hunan, China;Hengyang Medical School, The First Affiliated Hospital, Institute of Clinical Medicine, University of South China, Hengyang, Hunan, China;

关键词: atherosclerosis (AS);    vascular calcification (VC);    extracellular vesicles (EVs);    non-coding RNAs (ncRNAs);    uremia;   

DOI  :  10.3389/fmed.2023.1193660

 received in 2023-03-25, accepted in 2023-06-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Atherosclerosis (AS) is characterized by the accumulation of lipids, fibrous elements, and calcification in the innermost layers of arteries. Vascular calcification (VC), the deposition of calcium and phosphate within the arterial wall, is an important characteristic of AS natural history. However, medial arterial calcification (MAC) differs from intimal calcification and cannot simply be explained as the consequence of AS. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are directly involved in AS and VC processes. Understanding the communication between ECs and VSMCs is critical in revealing mechanisms underlying AS and VC. Extracellular vesicles (EVs) are found as intercellular messengers in kinds of physiological processes and pathological progression. Non-coding RNAs (ncRNAs) encapsulated in EVs are involved in AS and VC, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). The effects of ncRNAs have not been comprehensively understood, especially encapsulated in EVs. Some ncRNAs have demonstrated significant roles in AS and VC, but it remains unclear the functions of the majority ncRNAs detected in EVs. In this review, we summarize ncRNAs encapsulated in EC-EVs and VSMC-EVs, and the signaling pathways that are involved in AS and VC.

【 授权许可】

Unknown   
Copyright © 2023 Yu, Duan, Liu, Huang, Xiao and He.