Late-life depressive symptoms and white matter structural integrity within older Black adults

Frontiers in Aging Neuroscience

Aging Neuroscience

Shengwei Zhang¹  David A. Bennett¹  Namhee Kim¹  Konstantinos Arfanakis²  S. Duke Han³  Debra A. Fleischman⁴  Lisa L. Barnes⁴  Victoria N. Poole⁵  Sue E. Leurgans⁶  Melissa Lamar⁷ 

[1] Rush Alzheimer’s Disease Center, Chicago, IL, United States;Rush Alzheimer’s Disease Center, Chicago, IL, United States;Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, United States;Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States;Rush Alzheimer’s Disease Center, Chicago, IL, United States;Department of Family Medicine and Neurology, Keck School of Medicine, Los Angeles, CA, United States;Department of Psychology, University of Southern California, Los Angeles, CA, United States;School of Gerontology, University of Southern California, Los Angeles, CA, United States;Rush Alzheimer’s Disease Center, Chicago, IL, United States;Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States;Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, United States;Rush Alzheimer’s Disease Center, Chicago, IL, United States;Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, United States;Rush Alzheimer’s Disease Center, Chicago, IL, United States;Department of Preventive Medicine, Rush University Medical Center, Chicago IL, United States;Rush Alzheimer’s Disease Center, Chicago, IL, United States;Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, United States;

关键词: Black;    African-American;    late-life depressive symptoms;    brain structure;    diffusion-tensor imaging;   

DOI  :  10.3389/fnagi.2023.1138568

 received in 2023-01-05, accepted in 2023-04-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionOlder Black adults experience a high burden of depressive symptoms and cerebrovascular disease but the specific neurobiological substrates underlying the association between late-life depressive symptoms and brain integrity are understudied, particularly in within-group designs.MethodsUsing the Center for Epidemiologic Studies Depression Scale and diffusion-tensor imaging, within-Black variation in the association between late-life depressive symptoms and white matter structural integrity was examined in 297 older Black participants without dementia that were enrolled across three epidemiological studies of aging and dementia. Linear regression models were used to test associations with DTI metrics (fractional anisotropy, trace of the diffusion tensor) as the outcomes and depressive symptoms as the predictor, while adjusting for age, sex, education, scanner, serotonin-reuptake inhibitor use, total volume of white-matter hyperintensities normalized by intracranial volume, and presence of white-matter hyperintensities at the voxel level.ResultsHigher level of self-reported late-life depressive symptoms was associated with greater diffusion-tensor trace (reduced white matter integrity) in connections between commissural pathways and contralateral prefrontal regions (superior and middle frontal/dorsolateral prefrontal cortex), association pathways connecting dorsolateral prefrontal cortex with insular, striatal and thalamic regions, and association pathways connecting the parietal, temporal and occipital lobes and the thalamus.DiscussionThis study demonstrated a discernable pattern of compromised white matter structural integrity underlying late-life depressive symptoms within older Black adults.

【 授权许可】

Unknown   
Copyright © 2023 Fleischman, Arfanakis, Leurgans, Zhang, Lamar, Han, Poole, Kim, Bennett and Barnes.