Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19

Frontiers in Molecular Biosciences

Molecular Biosciences

Ricardo Conde¹  Chiara Bruzzone¹  Nieves Embade¹  José M. Mato²  Oscar Millet² 

[1]Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bilbao, Bizkaia, Spain

[2]Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bilbao, Bizkaia, Spain

[3]CIBERehd, Instituto de Salud Carlos III, Madrid, Spain

关键词: COVID-19;    SARS-CoV-2 infection;    metabolomics;    lipidomics;    NMR;    LC/GC-MS;    phenoreversion;    long covid;   

DOI  :  10.3389/fmolb.2023.1111482

 received in 2022-11-29, accepted in 2023-02-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

COVID-19 currently represents one of the major health challenges worldwide. Albeit its infectious character, with onset affectation mainly at the respiratory track, it is clear that the pathophysiology of COVID-19 has a systemic character, ultimately affecting many organs. This feature enables the possibility of investigating SARS-CoV-2 infection using multi-omic techniques, including metabolomic studies by chromatography coupled to mass spectrometry or by nuclear magnetic resonance (NMR) spectroscopy. Here we review the extensive literature on metabolomics in COVID-19, that unraveled many aspects of the disease including: a characteristic metabotipic signature associated to COVID-19, discrimination of patients according to severity, effect of drugs and vaccination treatments and the characterization of the natural history of the metabolic evolution associated to the disease, from the infection onset to full recovery or long-term and long sequelae of COVID.

【 授权许可】

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Copyright © 2023 Bruzzone, Conde, Embade, Mato and Millet.