Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice

Frontiers in Endocrinology

Endocrinology

Ayun Seol¹  Su Jin Lee¹  Ji Eun Kim¹  You Jeong Jin¹  Yu Jeong Roh¹  Hee Jin Song¹  So Hae Park¹  Dae Youn Hwang²  Jumin Park³  Sun Il Choi⁴  Bounleuane Douangdeuane⁵  Onevilay Souliya⁵ 

[1] Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of Korea;Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of Korea;Longevity Wellbeing Research Center/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of Korea;Department of Food Science and Nutrition, College of Human Ecology, Pusan National University, Busan, Republic of Korea;Henan Key Laboratory of Brain Targeted Bio-Nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, Kaifeng, Henan, China;Institute of Traditional Medicine, Ministry of Health, Vientiane, Laos;

关键词: anti-obesity;    D. tuberculatus;    lipogenesis;    lipolysis;    inflammasome;    β-oxidation;   

DOI  :  10.3389/fendo.2023.1167285

 received in 2023-02-16, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe therapeutic effects and mechanisms of Dipterocarpus tuberculatus (D. tuberculatus) extracts have been examined concerning inflammation, photoaging, and gastritis; however, their effect on obesity is still being investigated.MethodsWe administered a methanol extract of D. tuberculatus (MED) orally to Lep knockout (KO) mice for 4 weeks to investigate the therapeutic effects on obesity, weight gain, fat accumulation, lipid metabolism, inflammatory response, and β-oxidation.ResultsIn Lep KO mice, MED significantly reduced weight gains, food intake, and total cholesterol and glyceride levels. Similar reductions in fat weights and adipocyte sizes were also observed. Furthermore, MED treatment reduced liver weight, lipid droplet numbers, the expressions of adipogenesis and lipogenesis-related genes, and the expressions of lipolysis regulators in liver tissues. Moreover, the iNOS-mediated COX-2 induction pathway, the inflammasome pathway, and inflammatory cytokine levels were reduced, but β-oxidation was increased, in the livers of MED-treated Lep KO mice.ConclusionThe results of this study suggest that MED ameliorates obesity and has considerable potential as an anti-obesity treatment.

【 授权许可】

Unknown   
Copyright © 2023 Roh, Lee, Kim, Jin, Seol, Song, Park, Park, Douangdeuane, Souliya, Choi and Hwang