Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge

Frontiers in Oncology

Oncology

Caterina Gaudiano¹  Alberta Cappelli¹  Alessandro Bertaccini²  Lorenzo Bianchi²  Giulia Cuzzani³  Luigia Vetrone³  Riccardo Mei³  Stefano Fanti⁴  Paolo Castellucci⁵  Lucia Zanoni⁵  Francesca Giunchi⁶ 

[1] Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;Division of Urology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;Nuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy;Nuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy;Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;Pathology Unit, IRRCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;

关键词: [Ga]Ga-PSMA-PET/CT;    prostate cancer;    staging;    mini-invasive biopsy;    metastatic lymph node;   

DOI  :  10.3389/fonc.2023.1101221

 received in 2022-11-21, accepted in 2023-01-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

This is a case of [68 Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is a highly interesting case because, despite the advanced metastatic spread at initial presentation as showed by [68Ga]Ga-PSMA-PET/CT, the primary Pca was detected by none of the diagnostic techniques (12 random sample biopsy, mpMRI, PSMA PET/CT). However, [68Ga]Ga-PSMA-PET/CT showed a suspicious axillary lesion suitable for biopsy, which finally resulted as Pca metastasis. This case report is therefore a brilliant example of how [68Ga]Ga-PSMA-PET/CT optimized patient’s management.

【 授权许可】

Unknown   
Copyright © 2023 Vetrone, Cuzzani, Mei, Zanoni, Bertaccini, Bianchi, Castellucci, Gaudiano, Cappelli, Giunchi and Fanti