Role of oxidative stress in the relationship between periodontitis and systemic diseases

Frontiers in Physiology

Physiology

Youli Zheng¹  Haifeng Liu²  Jiaxin Shang²  Zheng Zhang² 

[1] The School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China;Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China;Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China;

关键词: periodontitis;    oxidative stress;    systemic diseases;    reactive oxygen species;    inflammation;   

DOI  :  10.3389/fphys.2023.1210449

 received in 2023-04-24, accepted in 2023-07-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Periodontitis is a common inflammatory disease. It is characterized by destruction of the supporting structures of the teeth and could lead to tooth loss and systemic inflammation. Bacteria in inflamed gingival tissue and virulence factors are capable of entering the bloodstream to induce systemic inflammatory response, thus influencing the pathological process of many diseases, such as cardiovascular diseases, diabetes, chronic kidney disease, as well as liver injury. An increasing body of evidence show the complex interplay between oxidative stress and inflammation in disease pathogenesis. When periodontitis occurs, increased reactive oxygen species accumulation leads to oxidative stress. Oxidative stress contributes to major cellular components damage, including DNA, proteins, and lipids. In this article, the focus will be on oxidative stress in periodontal disease, the relationship between periodontitis and systemic inflammation, and the impact of periodontal therapy on oxidative stress parameters.

【 授权许可】

Unknown   
Copyright © 2023 Shang, Liu, Zheng and Zhang.