Cooperation and competition between the default mode network and frontal parietal network in the elderly

Frontiers in Psychology

Psychology

Tetsuya Shimokawa¹  Mizuki Kaneda¹  Katsuki Higo¹  Miyuki Azuma¹  Seira Taniguchi¹  Hideya Koshino²  Ken Yaoi³  Naoyuki Osaka³  Takehiro Minamoto⁴  Mariko Osaka⁵ 

[1] Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Suita, Osaka, Japan;Department of Psychology, California State University, San Bernardino, CA, United States;Department of Psychology, Graduate School of Letters, Kyoto University, Kyoto, Japan;Graduate School of Human Sciences, Osaka University, Suita, Osaka, Japan;Graduate School of Human Sciences, Osaka University, Suita, Osaka, Japan;Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Suita, Osaka, Japan;

关键词: DMN;    FPN;    aging;    functional connectivity;    working memory;   

DOI  :  10.3389/fpsyg.2023.1140399

 received in 2023-01-09, accepted in 2023-04-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Recent research has shown that the Default Mode Network (DMN) typically exhibits increased activation during processing of social and personal information but shows deactivation during working memory (WM) tasks. Previously, we reported the Frontal Parietal Network (FPN) and DMN showed coactivation during task preparation whereas the DMN exhibited deactivation during task execution in working memory tasks. Aging research has shown that older adults exhibited decreased functional connectivity in the DMN relative to younger adults. Here, we investigated whether age-related cognitive decline is related to a reduced relationship between the FPN and DMN using a working memory task during the execution period. First, we replicated our previous finding that the FPN and DMN showed coactivation during the preparation period, whereas the DMN showed deactivation during the execution period. The older adults showed reduced DMN activity during task preparation and reduced deactivation during task execution; however, they exhibited a higher magnitude of activation in the FPN than the young individuals during task execution. Functional connectivity analyses showed that the elderly group, compared to the young group, showed weaker correlations within the FPN and the DMN, weaker positive correlations between the FPN and DMN during task preparation, and weaker negative correlations between the FPN and DMN during execution. The results suggest that cognitive decline in the older adults might be related to reduced connectivity within the DMN as well as between the FPN and DMN.

【 授权许可】

Unknown   
Copyright © 2023 Koshino, Osaka, Shimokawa, Kaneda, Taniguchi, Minamoto, Yaoi, Azuma, Higo and Osaka.