Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Frontiers in Pharmacology

Pharmacology

Sang Ho Lee¹  Kyung Hyun Choi²  Naina Sunildutt²  Abdul Rahim Chethikkattuveli Salih²  Pratibha Parihar² 

[1]College of Pharmacy, Jeju National University, Jeju, Republic of Korea

[2]Department of Mechatronics Engineering, Jeju National University, Jeju, Republic of Korea

关键词: organ on a chip (OCC);    disease modelling;    parameters;    drug discovery;    pharmacokinetic & pharmacodynamic parameters;   

DOI  :  10.3389/fphar.2023.1139229

 received in 2023-01-06, accepted in 2023-04-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device cultured with human living cells under specific organ shear stress which can faithfully replicate human organ-body level pathophysiology. This emerging organ-on-chip platform can be a remarkable alternative for animal models with a broad range of purposes in drug testing and precision medicine. Here, we review the parameters employed in using organ on chip platform as a plot mimic diseases, genetic disorders, drug toxicity effects in different organs, biomarker identification, and drug discoveries. Additionally, we address the current challenges of the organ-on-chip platform that should be overcome to be accepted by drug regulatory agencies and pharmaceutical industries. Moreover, we highlight the future direction of the organ-on-chip platform parameters for enhancing and accelerating drug discoveries and personalized medicine.

【 授权许可】

Unknown   
Copyright © 2023 Sunildutt, Parihar, Chethikkattuveli Salih, Lee and Choi.