Effects of the ketogenic diet on bone health: A systematic review

Frontiers in Endocrinology

Endocrinology

Aldo Eugenio Calogero¹  Vincenzo Garofalo¹  Sandro La Vignera¹  Rossella Cannarella¹  Rosita Angela Condorelli¹  Federica Barbagallo¹ 

[1] Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy;

关键词: ketogenic diet;    low-calorie ketogenic diet;    very-low-calorie ketogenic diet;    bone health;    osteoporosis;    bone mineral density;   

DOI  :  10.3389/fendo.2023.1042744

 received in 2022-09-12, accepted in 2023-01-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveTo carry out a systematic review of published studies to evaluate the relationship between different type of ketogenic diet (KD) and bone health as supported by the scientific literature.MethodsThe study involved all articles that assessed the relationship between the use of KD for the treatment of overweight or obesity and bone health. The quality assessment was evaluated with using the Cambridge Quality Checklists. The search strategy included the following combination of Medical Subjects Headings terms and keywords: “osteoporosis”, ”bone health, ”bone function”, ”bone mineral density”, and “ketogenic diet”.ResultsSeven trials were identified and reviewed. No significant changes in bone mass density (BMD) were observed after KD. The results showed no significant effect on bone resorption by measuring urinary N-telopeptide levels, on bone formation by measuring bone-specific alkaline phosphatase, or alterations in overall bone turnover in patients who followed KD. Only in female subject after a 10% weight loss, bone resorption increases while new bone synthesis decreases, but without increasing the risk of osteoporosis. Finally, patients on KD lost significantly more weight than controls, associated with an increase in serum vitamin D levels and a reduction in plasma parathyroid hormone (PTH) levels.ConclusionNo human studies have currently been conducted with adequate and powerful experimental designs to definitively understand the impact of KD therapy on bone health.

【 授权许可】

Unknown   
Copyright © 2023 Garofalo, Barbagallo, Cannarella, Calogero, La Vignera and Condorelli