Seipin—still a mysterious protein?

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Veijo T. Salo¹ 

[1] null;

关键词: seipin;    lipid droplet;    lipid droplet-ER contact sites;    membrane contact site;    endoplasmic reticulum;    mitochondria-ER contact sites;   

DOI  :  10.3389/fcell.2023.1112954

 received in 2022-11-30, accepted in 2023-01-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cells store excess energy in the form of lipid droplets (LDs), a specialized sub-compartment of the endoplasmic reticulum (ER) network. The lipodystrophy protein seipin is a key player in LD biogenesis and ER-LD contact site maintenance. Recent structural and in silico studies have started to shed light on the molecular function of seipin as a LD nucleator in early LD biogenesis, whilst new cell biological work implies a role for seipin in ER-mitochondria contact sites and calcium metabolism. In this minireview, I discuss recent insights into the molecular function of seipin.

【 授权许可】

Unknown   
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