Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study

Frontiers in Medicine

Medicine

Federica Derlino¹  Carlo Tomasini¹  Andrea Michelerio¹  Valeria Brazzelli¹  Giacomo Fiandrino²  Marco Paulli²  Irene Defrancesco³  Chiara Cavalloni³  Marzia Varettoni³  Luca Arcaini³  Camilla Vassallo⁴  Mara De Amici⁵ 

[1] Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy;Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;Department of Molecular Medicine, University of Pavia, Pavia, Italy;Department of Pathology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;Department of Molecular Medicine, University of Pavia, Pavia, Italy;Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;Laboratory of Immuno-Allergology of Clinical Chemistry and Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;

关键词: eosinophilic dermatosis;    insect bites;    B cell chronic lymphocytic leukemia;    non-Hodgkin lymphoma;    eosinophils;   

DOI  :  10.3389/fmed.2023.1231003

 received in 2023-05-29, accepted in 2023-07-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear.ObjectiveTo describe the clinical, pathological and immunological findings in a series of oncohematological patients with EDHM.MethodsAn observational prospective cohort study of oncohematological patients receiving a diagnosis of EDHM between April 2017 and December 2018.ResultsA total of 15 patients with EDHM (10 females and 5 males) were identified among 422 oncohematological patients. Disease presentation varied from firm erythematous papules to more polymorphic presentations. The lesions were most prevalent on the exposed sites, 8/15 patients recalled an insect bite. Lesion seasonality was reported in 13/15 patients. IgE levels were elevated in six patients, circulating IL-4 and IL-5 were within a normal range. Twelve out of 15 patients developed skin manifestations after chemotherapy. The infiltrate could be eosinophil-rich or lymphocytic-rich. Interestingly, the histopathologic findings were in accordance with arthropod bites.ConclusionA role for insect bites in EDHM is supported by our findings. EDHM may be related to aggressive hematologic disease.

【 授权许可】

Unknown   
Copyright © 2023 Michelerio, Tomasini, Fiandrino, De Amici, Varettoni, Defrancesco, Cavalloni, Brazzelli, Derlino, Paulli, Arcaini and Vassallo.