Comparison of long-term complications in cancer patients with incidental and acute symptomatic venous thromboembolism

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

María Barca-Hernando¹  Samira Marin-Romero¹  Sergio Lopez-Ruz¹  Luis Jara-Palomares²  Teresa Elias-Hernandez²  Remedios Otero-Candelera² 

[1] Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, Sevilla, Spain;Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, Sevilla, Spain;Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain;

关键词: neoplasms;    incidental;    venous thromboembolism;    venous thrombosis;    hemorrhage;    mortality;   

DOI  :  10.3389/fcvm.2023.1118385

 received in 2022-12-07, accepted in 2023-04-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundClinical practice guidelines recommend that patients with incidental venous thromboembolism (VTE) receive the same anticoagulant therapy as those with symptomatic VTE. We aimed to compare the rate of complications between cancer patients with incidental and symptomatic VTE through a long-term follow-up cohort.MethodsWe performed a post hoc analysis of prospective studies of cancer patients with VTE between 2008 and 2019, with the primary outcome of rates of recurrent VTE and clinically relevant bleeding (CRB) in incidental and symptomatic VTE groups.ResultsIn total, 796 patients were included, of which 42.8% had incidental VTE. No significant differences were noted in the rate of recurrent VTE (0.4 per 100 patients/month vs. 0.5 per 100 patients/month; p = 0.313) and in the rate of CRB (0.6 per 100 patients/month vs. 0.5 per 100 patients/month; p = 0.128) between patients with incidental VTE and symptomatic VTE, respectively. At six-month follow-ups, the cumulative incidence of CRB was significantly higher in patients with incidental VTE than that in those with symptomatic VTE (7.9% vs. 4.4%, respectively; OR: 1.8; 95% CI: 1.01–3.2).ConclusionCancer patients with incidental VTE had similar rates of CRB and VTE recurrence in long-term follow-up compared with patients with symptomatic VTE. At six-month follow-ups, patients with incidental VTE had a higher cumulative incidence of CRB than those with symptomatic VTE.

【 授权许可】

Unknown   
© 2023 Barca-Hernando, Lopez-Ruz, Marin-Romero, Elias-Hernandez, Otero-Candelera and Jara-Palomares.