Manipulation of glycogen and sucrose synthesis increases photosynthetic productivity in cyanobacteria

Frontiers in Microbiology

Microbiology

Jacob Sebesta¹  Katherine J. Chou¹  Michael Cantrell¹  Wei Xiong¹  Melissa Cano¹  Troy Paddock¹  Jianping Yu² 

[1] Biosciences Center, National Renewable Energy Laboratory, Golden, CO, United States;null;

关键词: photosynthesis;    cyanobacteria;    glycogen;    sucrose;    ATP;   

DOI  :  10.3389/fmicb.2023.1124274

 received in 2022-12-14, accepted in 2023-05-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Photosynthetic productivity is limited by low energy conversion efficiency in naturally evolved photosynthetic organisms, via multiple mechanisms that are not fully understood. Here we show evidence that extends recent findings that cyanobacteria use “futile” cycles in the synthesis and degradation of carbon compounds to dissipate ATP. Reduction of the glycogen cycle or the sucrose cycle in the model cyanobacterium Synechocystis 6803 led to redirection of cellular energy toward faster growth under simulated outdoor light conditions in photobioreactors that was accompanied by higher energy charge [concentration ratio of ATP/(ATP + ADP)]. Such manipulation of energy metabolism may have potential in engineering microalgal chassis cells to increase productivity of biomass or target metabolites.

【 授权许可】

Unknown   
Copyright © 2023 Cantrell, Cano, Sebesta, Paddock, Xiong, Chou and Yu.