Treatment of condylomata acuminata caused by low-risk human papillomavirus with chloroquine phosphate gel

Frontiers in Medicine

Medicine

Jie Huang¹  Wei Yang²  Zhisheng Guan³  Qi Liu³  Manli Yuan³  Xiangling Li⁴  Junlong Yu⁵ 

[1] Department of Dermatology, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China;Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd, Guangzhou, Guangdong, China;Guangzhou Hybribio Biotechnology Technology Co., Ltd., Guangzhou, Guangdong, China;Key Laboratory of Basic Research of Traditional Chinese Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China;School of Basic Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China;

关键词: chloroquine phosphate;    human papillomavirus;    condylomata acuminata;    anogenital warts;    p53;   

DOI  :  10.3389/fmed.2023.1171550

 received in 2023-02-22, accepted in 2023-04-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveTo observe the stability and therapeutic effect of chloroquine phosphate gel on human condylomata acuminata (CA) caused by low-risk human papillomavirus (HPV).MethodsThe appearance, viscosity, pH, chloroquine concentration, deethylchloroquine concentration and content uniformity of chloroquine phosphate gel were examined for 24 months, the gel met the quality standards throughout the 24-month observation. A nude mouse model harboring CA xenografts was used to observe the therapeutic effect of this gel on CA in vivo.ResultsAfter 14 days of gel administration, compared with the control group, the treatment group had significantly smaller warts and significantly reduced DNA copy numbers of HPV6 and HPV11 in the wart tissues. Immunohistochemistry analysis of p53 protein expression in the wart tissues of the treatment group was significantly increased.ConclusionChloroquine phosphate gel was stable and effective against CA, possibly through the promotion of p53 protein expression to induce apoptosis, leading to the involution of warts.

【 授权许可】

Unknown   
Copyright © 2023 Li, Guan, Liu, Yang, Huang, Yuan and Yu.