Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism

Frontiers in Physiology

Physiology

Li’e Xue¹  Hongbin Song¹  Jieqiong Shen¹  Jiacheng Cao¹  Yinhua Yang¹  Tianfang Xiao¹  Fanglu Zhao¹  Jing Wang¹  Yue Yang¹  Weimin Lin²  Ruiyi Lin³ 

[1] College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, China;[e-mail];null;

关键词: skeletal muscle;    adipose tisse;    myokine;    IL-6;    lipids metabolism;   

DOI  :  10.3389/fphys.2023.1110926

 received in 2022-11-29, accepted in 2023-07-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

The detrimental impact of obesity on human health is increasingly evident with the rise in obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance metabolism, plays a significant role as a secretory organ by releasing various myokines. Among these myokines, interleukin 6 (IL-6) is closely associated with skeletal muscle contraction. IL-6 triggers the process of lipolysis by mobilizing energy-storing adipose tissue, thereby providing energy for physical exercise. This phenomenon also elucidates the health benefits of regular exercise. However, skeletal muscle and adipose tissue maintain a constant interaction, both directly and indirectly. Direct interaction occurs through the accumulation of excess fat within skeletal muscle, known as ectopic fat deposition. Indirect interaction takes place when adipose tissue is mobilized to supply the energy for skeletal muscle during exercise. Consequently, maintaining a functional balance between skeletal muscle and adipose tissue becomes paramount in regulating energy metabolism and promoting overall health. IL-6, as a representative cytokine, participates in various inflammatory responses, including non-classical inflammatory responses such as adipogenesis. Skeletal muscle influences adipogenesis through paracrine mechanisms, primarily by secreting IL-6. In this research paper, we aim to review the role of skeletal muscle-derived IL-6 in lipid metabolism and other physiological activities, such as insulin resistance and glucose tolerance. By doing so, we provide valuable insights into the regulatory function of skeletal muscle-derived myokines in lipid metabolism.

【 授权许可】

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Copyright © 2023 Lin, Song, Shen, Wang, Yang, Yang, Cao, Xue, Zhao, Xiao and Lin.