Effects of a false-positive result in newborn congenital hypothyroidism screening on parents in Guangxi, China

Frontiers in Pediatrics

Pediatrics

Xiao-Fei Zhang¹  Bu-Tong Chen²  Yu-Jia Wei³  Bai-Qing Dong³  Si-Jing Tu⁴  Chao Luo⁵ 

[1] Department of Pediatrics, The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China;School of Humanities and Social Sciences, Guangxi Medical University, Nanning, China;School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China;School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China;School of Public Health, Hangzhou Normal University, Hangzhou, China;Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

关键词: newborn screening;    false-positive;    congenital hypothyroidism;    parenting stress index;    health education;   

DOI  :  10.3389/fped.2023.1134923

 received in 2022-12-31, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundAs more than 500,000 neonates participate in newborn congenital hypothyroidism (CH) screening in Guangxi Zhuang Autonomous Region each year, the overall number of false-positive (FP) cases has increased. We aim to assess the parental stress in parents of neonates with FP CH results in Guangxi, find out the influence factors related to demographics, and provide the basis for personalized health education.MethodsThe parents of neonates with FP CH results were invited to participate in the FP group, and the parents of neonates with all negative results were invited to participate in the control group. The parents completed a questionnaire on demographics, knowledge of CH, and the parental stress index (PSI) in the hospital for the first time. The follow-up visits for PSI were conducted 3, 6, and 12 months afterward through telephone and online.ResultsA total of 258 and 1,040 parents participated in the FP and control groups, respectively. The parents in the FP group had better knowledge of CH and higher PSI scores than the parents in the control group. The result of logistic regression showed that the major influence factors related to the knowledge of CH were FP experience and source of knowledge. The parents in the FP group who were well-informed during the recall phone call had lower PSI scores than the other parents. The parents in the FP group showed decreasing PSI scores gradually in follow-up visits.ConclusionThe results suggested that FP screening results may affect parental stress and parent–child relationship. FP results increased the stress on the parents and increased their knowledge of CH passively.

【 授权许可】

Unknown   
© 2023 Tu, Wei, Chen, Zhang, Luo and Dong.