Function of TRP channels in monocytes/macrophages

Frontiers in Immunology

Immunology

Jingyu Xu¹  Rui Xie¹  Ya Deng²  Jiangbo Wu²  Qi Liu²  Jiajing Li²  Qimin An²  Xianli Wu²  Zhuo Li²  Yanxia Hu²  Xingyi Mu²  Dongdong Fan²  Ting Zhang²  Qian Du²  Xianmin Lu²  Yiwei Xiang²  Siqi Tang²  Chen Luo² 

[1] Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China;Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China;The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China;

关键词: monocytes;    macrophage;    TRP channels;    macrophage polarization;    system disease;   

DOI  :  10.3389/fimmu.2023.1187890

 received in 2023-03-18, accepted in 2023-06-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc. It has been reported that various TRP channels are expressed in mammalian macrophages. TRP channels may be involved in various signaling pathways in the development of various systemic diseases through changes in intracellular concentrations of cations such as calcium and magnesium. These TRP channels may also intermingle with macrophage activation signals to jointly regulate the occurrence and development of diseases. Here, we summarize recent findings on the expression and function of TRP channels in macrophages and discuss their role as modulators of macrophage activation and function. As research on TRP channels in health and disease progresses, it is anticipated that positive or negative modulators of TRP channels for treating specific diseases may be promising therapeutic options for the prevention and/or treatment of disease.

【 授权许可】

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Copyright © 2023 Wu, Li, Deng, Lu, Luo, Mu, Zhang, Liu, Tang, Li, An, Fan, Xiang, Wu, Hu, Du, Xu and Xie